Well, it's not just Big...all established businesses hate competition.
Why do many cities limit the number of taxis allowed? Because the existing companies don't want competition.
Why do many states require 1500 hours of beauty school instruction (at least, that was WA's standard) before someone is allowed to simply braid hair? Existing beauty parlors don't want competition
Why did the tattoo/piercing people in WA try to get the state the implement a licensing scheme (when there was already a perfectly adequate set of hygiene standards)? To create a barrier to competition.
Why do some states require licensing for such occupations as interior decorators and florists?
I think you get the picture. Existing business interests, large or small, have a profound tendency to, when possible, get the government to do the dirty work of keeping competitors out of the market. This is usually done in the name of "public health/safety" or insuring "product quality"