Methotrexate is also used for treating rheumatoid arthritis. I know several people in my church who are on it. One of them just turned sixty, and is working 6 days a week in a very physical job trying to make double payments to the mortgage. This person is in a race against the clock - "can I work long enough so that when my body finally quits, my SS and pensions will be enough to cover the house payment?" Methotrexate slows down the clock, allowing another week of work. I shudder to think what would happen if it wasn't available. Hell, I shudder just thinking about that situation, WITH the drug.